Journal: Biochemical and biophysical research communications

Article Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reliance on fats as a fuel source independently of diet: evidence that diminished carbohydrate supply contributes to dioxin lethality.

doi: 10.1016/0006-291x(91)91558-t

Figure Lengend Snippet: FIGURE 2, Effect of aminocarnitine on the RQs of dioxane and TCDD-treated chick embryos. Four batches of eight embryos were treated at 11 days, two with 0.01 ml dioxane (controls) and two with 1 nmol of TCDD in 0.01 ml dioxane. A. On day 17, one batch of dioxane-control and one of TCDD-treated eggs were injected with 20 Fmol aminocarnitine per egg. B. On day 20, the remaining batches were injected with 30 pmol aminocarnitine per egg. RQs were determined in each batch for one hour, after which the embryos were removed, injected with aminocarnitine and immediately returned to the Oxymax chambers to continue RQ determinations. Similar experiments were repeated several times; the results shown are representative. The ordinate scales for A and B are the same. Each circle represents the mean RQ for determinations taken every 10 minutes over a one hour period for a batch of eggs. The first circle shows the mean RQ for the hour before aminocarnitine was injected. 0 treated with 0.01 ml dioxane (controls); 0 treated with 1 nmol TCDD in 0.01 ml dioxane.

Article Snippet: RQs (14) were measured on groups of eight eggs in an Oxymax Instrument, Columbus Instruments, Columbus, OH.

Techniques: Control, Injection