74a Search Results


trpv3 antagonist 74a medchemexpress hy  (MedChemExpress)
91
MedChemExpress trpv3 antagonist 74a medchemexpress hy
Trpv3 Antagonist 74a Medchemexpress Hy, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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trpv3 channel antagonist trpv3 74a  (Tocris)
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conjugation  (Ellman International Inc)
86
Ellman International Inc conjugation
Conjugation, supplied by Ellman International Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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acrylic latex joncryl® 74-a  (BASF)
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BASF acrylic latex joncryl® 74-a
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trpv3 antagonist 74a  (AbbVie Inc)
90
AbbVie Inc trpv3 antagonist 74a
The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
Trpv3 Antagonist 74a, supplied by AbbVie Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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latex joncryl 74a  (BASF)
90
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The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
Latex Joncryl 74a, supplied by BASF, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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joncryl 74-a  (BASF)
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The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
Joncryl 74 A, supplied by BASF, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lt33-74a  (Starfire Systems Inc)
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Starfire Systems Inc lt33-74a
The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
Lt33 74a, supplied by Starfire Systems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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xyloglucanase 74a  (NZYTech Inc)
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NZYTech Inc xyloglucanase 74a
The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
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anti-dansyl mige a (27-74 a )  (Becton Dickinson)
90
Becton Dickinson anti-dansyl mige a (27-74 a )
The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
Anti Dansyl Mige A (27 74 A ), supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pump array 34 including pumps 74a–74j  (Penn Engineering Components Inc)
90
Penn Engineering Components Inc pump array 34 including pumps 74a–74j
The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
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joncryltm 74a  (BASF)
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BASF joncryltm 74a
The 3D-structure of mouse <t>TRPV3</t> in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.
Joncryltm 74a, supplied by BASF, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


The 3D-structure of mouse TRPV3 in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.

Journal: International Journal of Molecular Sciences

Article Title: TRPV3 Ion Channel: From Gene to Pharmacology

doi: 10.3390/ijms24108601

Figure Lengend Snippet: The 3D-structure of mouse TRPV3 in a closed apo-state (PDB: 6DVW). ( A ) Side and ( B ) top views of the tetramer protein. Individual subunits are colored in red, cyan, yellow, and slate. ( C ) The structural organization of a single subunit with domain mapping.

Article Snippet: A potent and selective TRPV3 antagonist 74a from AbbVie Inc. demonstrated a favorable preclinical profile in two different models of neuropathic pain as compared to the reference drug, gabapentin, and evoked antinociception in a reserpine model of central pain, but effective doses (30–100 mg/kg) were too high for further development [ ].

Techniques:

Agonists of TRPV3 ion channel.

Journal: International Journal of Molecular Sciences

Article Title: TRPV3 Ion Channel: From Gene to Pharmacology

doi: 10.3390/ijms24108601

Figure Lengend Snippet: Agonists of TRPV3 ion channel.

Article Snippet: A potent and selective TRPV3 antagonist 74a from AbbVie Inc. demonstrated a favorable preclinical profile in two different models of neuropathic pain as compared to the reference drug, gabapentin, and evoked antinociception in a reserpine model of central pain, but effective doses (30–100 mg/kg) were too high for further development [ ].

Techniques:

Antagonists of TRPV3 ion channel.

Journal: International Journal of Molecular Sciences

Article Title: TRPV3 Ion Channel: From Gene to Pharmacology

doi: 10.3390/ijms24108601

Figure Lengend Snippet: Antagonists of TRPV3 ion channel.

Article Snippet: A potent and selective TRPV3 antagonist 74a from AbbVie Inc. demonstrated a favorable preclinical profile in two different models of neuropathic pain as compared to the reference drug, gabapentin, and evoked antinociception in a reserpine model of central pain, but effective doses (30–100 mg/kg) were too high for further development [ ].

Techniques:

TRPV3 binding sites of exogenous ligands from cryo-EM data. ( A ) The architecture of a single TRPV3 subunit is presented as a topological diagram. Protein data bank (PDB) accession IDs are given in parentheses. The data shown refer to mouse TRPV3 unless noted otherwise. AR1–6—ankyrin repeats 1–6, ARD-TM—ankyrin-repeat domain- transmembrane domain, hTRPV3—human TRPV3, β1–3—β-strands 1–3, LH1–2—linker helix 1–2, P—pore helix, pre-S1—pre-S1-helix, S1–S6—transmembrane segments 1–6, TM—transmembrane. ( B ) The 3D view of the binding sites on a single TRPV3 subunit mapped by different colors.

Journal: International Journal of Molecular Sciences

Article Title: TRPV3 Ion Channel: From Gene to Pharmacology

doi: 10.3390/ijms24108601

Figure Lengend Snippet: TRPV3 binding sites of exogenous ligands from cryo-EM data. ( A ) The architecture of a single TRPV3 subunit is presented as a topological diagram. Protein data bank (PDB) accession IDs are given in parentheses. The data shown refer to mouse TRPV3 unless noted otherwise. AR1–6—ankyrin repeats 1–6, ARD-TM—ankyrin-repeat domain- transmembrane domain, hTRPV3—human TRPV3, β1–3—β-strands 1–3, LH1–2—linker helix 1–2, P—pore helix, pre-S1—pre-S1-helix, S1–S6—transmembrane segments 1–6, TM—transmembrane. ( B ) The 3D view of the binding sites on a single TRPV3 subunit mapped by different colors.

Article Snippet: A potent and selective TRPV3 antagonist 74a from AbbVie Inc. demonstrated a favorable preclinical profile in two different models of neuropathic pain as compared to the reference drug, gabapentin, and evoked antinociception in a reserpine model of central pain, but effective doses (30–100 mg/kg) were too high for further development [ ].

Techniques: Binding Assay, Cryo-EM Sample Prep

Analgesic efficacies of TRPV3 inhibitors.

Journal: International Journal of Molecular Sciences

Article Title: TRPV3 Ion Channel: From Gene to Pharmacology

doi: 10.3390/ijms24108601

Figure Lengend Snippet: Analgesic efficacies of TRPV3 inhibitors.

Article Snippet: A potent and selective TRPV3 antagonist 74a from AbbVie Inc. demonstrated a favorable preclinical profile in two different models of neuropathic pain as compared to the reference drug, gabapentin, and evoked antinociception in a reserpine model of central pain, but effective doses (30–100 mg/kg) were too high for further development [ ].

Techniques: Hot Plate Test, Tail Flick Test, Adjuvant, Ligation

Antipruritic efficacies of TRPV3 inhibitors.

Journal: International Journal of Molecular Sciences

Article Title: TRPV3 Ion Channel: From Gene to Pharmacology

doi: 10.3390/ijms24108601

Figure Lengend Snippet: Antipruritic efficacies of TRPV3 inhibitors.

Article Snippet: A potent and selective TRPV3 antagonist 74a from AbbVie Inc. demonstrated a favorable preclinical profile in two different models of neuropathic pain as compared to the reference drug, gabapentin, and evoked antinociception in a reserpine model of central pain, but effective doses (30–100 mg/kg) were too high for further development [ ].

Techniques: