Journal: Journal of Endocrinology

Article Title: Protection of pancreatic β-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies

doi: 10.1677/joe-06-0148

Figure Lengend Snippet: Figure 1 Daily profiles of plasma glucose levels in nTg and CaMTg mice treated with exendin-4 or saline. Exendin-4 (28 nmol/initial kg BW per day) was given subcutaneously and continuously over 2 weeks through osmotic minipumps transplanted on day 14 after birth. Blood samples were taken daily by tail cutting, and plasma glucose levels were measured using a compact glucose analyzer. Open circles, CaMTg mice treated with saline (nZ21). Closed circles, CaMTg mice treated with exendin-4 (nZ13). Open squares, nTg mice treated with saline (nZ13). Closed squares, nTg mice treated with exendin-4 (nZ7). Each symbol represents a meanCS.E.M. value. *P!0.05, †P!0.01, as compared with the corresponding value in the saline-treated CaMTg mice.

Article Snippet: Osmotic minipumps (model 1002, Alzet, Cupertino, CA, USA) were implanted in the midscapular region at the end of the second week after birth, and exendin-4 (10 mg per pump, equivalent to z28 nmol/initial kg BW per day) dissolved in saline was subcutaneously injected during the following 2 weeks.

Techniques: Clinical Proteomics, Saline