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Tf1, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, <t>TF1)</t> and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.
Tf 1 Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, <t>TF1)</t> and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, <t>TF1)</t> and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.
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cell culture  (ATCC)
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, <t>TF1)</t> and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, <t>TF1)</t> and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, <t>TF1)</t> and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.
Nitrogen, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, TF1) and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.

Journal: Blood Neoplasia

Article Title: Comparison of the enzymatic and cellular profiles of clinical JAK inhibitors for the treatment of myelofibrosis

doi: 10.1016/j.bneo.2026.100206

Figure Lengend Snippet: Cytotoxicity assessment on JAK2-dependent and non-JAK2–dependent AML cell lines. Quantification of the effects of JAKinibs on the viability of JAK2 dependent cells (on-target: SET2, F36P, TF1) and JAK2 independent cells (off-target: EOL1, MV4-11, MOLM16) in assays using a CellTiter-Glo assay following treatment for 72 hours with JAKinibs at indicated concentrations. C max,ss and C avg,ss per drug are indicated with vertical lines. Values are provided in . AML, acute myeloid leukemia; C avg,ss , average steady-state plasma drug concentration during multiple-dose administration; C max.ss , maximum steady-state plasma drug concentration during a dosage interval; GeoMean, geometric mean.

Article Snippet: JAKinib cytotoxicity was assessed in human SET2 (DSMZ), F36-P (DSMZ), TF1 (ATCC), EOL1 (DSMZ), MV-4-11 (ATCC) and MOLM-16 (DSMZ) cell lines treated with serial dilutions of JAKinibs (0.5nM to 10μM; ).

Techniques: Glo Assay, Clinical Proteomics, Concentration Assay