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In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. <t>(C)</t> <t>SPECT/CT</t> imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.
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In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. <t>(C)</t> <t>SPECT/CT</t> imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.
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In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. (C) SPECT/CT imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.

Journal: Biomaterials

Article Title: A 177 Lu-nucleotide Coordination Polymer-incorporated Thermosensitive Hydrogel with Anti-inflammatory and Chondroprotective Capabilities for Osteoarthritis Treatment

doi: 10.1016/j.biomaterials.2025.123098

Figure Lengend Snippet: In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. (C) SPECT/CT imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.

Article Snippet: Static SPECT scans were conducted at 1 h, 2 d, 4 d, and 16 d post-injection using a SPECT/CT scanner (Precedence 16, Philips, Netherlands).

Techniques: In Vivo, Injection, Single Photon Emission Computed Tomography, Imaging, Ex Vivo