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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM <t>SKA121</t> (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.
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Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM SKA121 (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.

Journal: International Journal of Molecular Sciences

Article Title: Transcriptional Repression of CCL2 by K Ca 3.1 K + Channel Activation and LRRC8A Anion Channel Inhibition in THP-1-Differentiated M 2 Macrophages

doi: 10.3390/ijms26157624

Figure Lengend Snippet: Effects of K Ca 3.1 activation and LRRC8A inhibition on CCL2 expression and secretion in M 2 -MACs. ( A , B ): Real-time PCR examination of CCL22 ( A ) and CCL2 ( B ) expression in native THP-1 cells (native) and M 2 -MACs (M 2 ) ( n = 4). Data are normalized to ACTB. ( C , D , F , G ): Real-time PCR examination of CCL22 ( C , F ) and CCL2 ( D , G ) expression following treatment with vehicle, 10 μM SKA121 (SKA) ( C , D ), or 10 μM endovion (EDV) ( F , G ) for 12 h in M 2 -MACs ( n = 4). Expression levels are normalized to ACTB and shown relative to vehicle control (set as 1.0). ( E , H ): ELISA quantification of CCL2 secretion after 24 h treatment with SKA ( E ) or EDV ( H ) in M 2 -MACs ( n = 4). Secretion levels are shown relative to vehicle control (set as 1.0). **: p < 0.01 vs. native THP-1 or vehicle control.

Article Snippet: EDV (HY-105917), SKA121 (HY-107414), SP600125 (HY-12041), and PD169316 (HY-10578) were from MedChemExpress (Monmouth Junction, NJ, USA).

Techniques: Activation Assay, Inhibition, Expressing, Real-time Polymerase Chain Reaction, Control, Enzyme-linked Immunosorbent Assay