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<t>Single-cell</t> <t>analysis</t> reveals that ZBTB7A expression localizes to malignant epithelial cells and is associated with aggressive phenotypes. This figure was generated using Seurat. (A) UMAP plot showing cell type clustering. (B) Marker gene expression of different cell clusters. (C) Tumor signature score for lineage markers. (D) Monocyte score for lineage markers. (E) Fibroblast signature score for lineage markers. (F) T cell signature score for lineage markers. (G) Endothelial signature score for lineage markers. (H) B cell score for lineage markers. (I) Stratification of tumor cells into ZBTB7A-high and ZBTB7A-low subsets. Enrichment of (J) migration, (K) EMT and (L) proliferation programs in ZBTB7A-high tumor cells. Pathway scores show increased (M) Wnt/β-catenin and (N) Hippo-YAP signaling in ZBTB7A-high cells. EMT, epithelial-mesenchymal transition; UMAP, Uniform Manifold Approximation and Projection; ZBTB7A, zinc finger and BTB domain-containing 7A.
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<t>Single-cell</t> <t>analysis</t> reveals that ZBTB7A expression localizes to malignant epithelial cells and is associated with aggressive phenotypes. This figure was generated using Seurat. (A) UMAP plot showing cell type clustering. (B) Marker gene expression of different cell clusters. (C) Tumor signature score for lineage markers. (D) Monocyte score for lineage markers. (E) Fibroblast signature score for lineage markers. (F) T cell signature score for lineage markers. (G) Endothelial signature score for lineage markers. (H) B cell score for lineage markers. (I) Stratification of tumor cells into ZBTB7A-high and ZBTB7A-low subsets. Enrichment of (J) migration, (K) EMT and (L) proliferation programs in ZBTB7A-high tumor cells. Pathway scores show increased (M) Wnt/β-catenin and (N) Hippo-YAP signaling in ZBTB7A-high cells. EMT, epithelial-mesenchymal transition; UMAP, Uniform Manifold Approximation and Projection; ZBTB7A, zinc finger and BTB domain-containing 7A.
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<t>Single-cell</t> <t>analysis</t> reveals that ZBTB7A expression localizes to malignant epithelial cells and is associated with aggressive phenotypes. This figure was generated using Seurat. (A) UMAP plot showing cell type clustering. (B) Marker gene expression of different cell clusters. (C) Tumor signature score for lineage markers. (D) Monocyte score for lineage markers. (E) Fibroblast signature score for lineage markers. (F) T cell signature score for lineage markers. (G) Endothelial signature score for lineage markers. (H) B cell score for lineage markers. (I) Stratification of tumor cells into ZBTB7A-high and ZBTB7A-low subsets. Enrichment of (J) migration, (K) EMT and (L) proliferation programs in ZBTB7A-high tumor cells. Pathway scores show increased (M) Wnt/β-catenin and (N) Hippo-YAP signaling in ZBTB7A-high cells. EMT, epithelial-mesenchymal transition; UMAP, Uniform Manifold Approximation and Projection; ZBTB7A, zinc finger and BTB domain-containing 7A.
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<t>Single-cell</t> <t>analysis</t> reveals that ZBTB7A expression localizes to malignant epithelial cells and is associated with aggressive phenotypes. This figure was generated using Seurat. (A) UMAP plot showing cell type clustering. (B) Marker gene expression of different cell clusters. (C) Tumor signature score for lineage markers. (D) Monocyte score for lineage markers. (E) Fibroblast signature score for lineage markers. (F) T cell signature score for lineage markers. (G) Endothelial signature score for lineage markers. (H) B cell score for lineage markers. (I) Stratification of tumor cells into ZBTB7A-high and ZBTB7A-low subsets. Enrichment of (J) migration, (K) EMT and (L) proliferation programs in ZBTB7A-high tumor cells. Pathway scores show increased (M) Wnt/β-catenin and (N) Hippo-YAP signaling in ZBTB7A-high cells. EMT, epithelial-mesenchymal transition; UMAP, Uniform Manifold Approximation and Projection; ZBTB7A, zinc finger and BTB domain-containing 7A.
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Single-cell analysis reveals that ZBTB7A expression localizes to malignant epithelial cells and is associated with aggressive phenotypes. This figure was generated using Seurat. (A) UMAP plot showing cell type clustering. (B) Marker gene expression of different cell clusters. (C) Tumor signature score for lineage markers. (D) Monocyte score for lineage markers. (E) Fibroblast signature score for lineage markers. (F) T cell signature score for lineage markers. (G) Endothelial signature score for lineage markers. (H) B cell score for lineage markers. (I) Stratification of tumor cells into ZBTB7A-high and ZBTB7A-low subsets. Enrichment of (J) migration, (K) EMT and (L) proliferation programs in ZBTB7A-high tumor cells. Pathway scores show increased (M) Wnt/β-catenin and (N) Hippo-YAP signaling in ZBTB7A-high cells. EMT, epithelial-mesenchymal transition; UMAP, Uniform Manifold Approximation and Projection; ZBTB7A, zinc finger and BTB domain-containing 7A.

Journal: Oncology Reports

Article Title: ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

doi: 10.3892/or.2026.9107

Figure Lengend Snippet: Single-cell analysis reveals that ZBTB7A expression localizes to malignant epithelial cells and is associated with aggressive phenotypes. This figure was generated using Seurat. (A) UMAP plot showing cell type clustering. (B) Marker gene expression of different cell clusters. (C) Tumor signature score for lineage markers. (D) Monocyte score for lineage markers. (E) Fibroblast signature score for lineage markers. (F) T cell signature score for lineage markers. (G) Endothelial signature score for lineage markers. (H) B cell score for lineage markers. (I) Stratification of tumor cells into ZBTB7A-high and ZBTB7A-low subsets. Enrichment of (J) migration, (K) EMT and (L) proliferation programs in ZBTB7A-high tumor cells. Pathway scores show increased (M) Wnt/β-catenin and (N) Hippo-YAP signaling in ZBTB7A-high cells. EMT, epithelial-mesenchymal transition; UMAP, Uniform Manifold Approximation and Projection; ZBTB7A, zinc finger and BTB domain-containing 7A.

Article Snippet: According to the original publication, the dataset consists of 10X Genomics single-cell RNA sequencing from five cases of high-grade serous ovarian carcinoma (HGSOC), yielding a total of 42,000 tumor-associated cells.

Techniques: Single-cell Analysis, Expressing, Generated, Marker, Gene Expression, Migration