Journal: Cancer Science

Article Title: SLAMF6 Enhances the Efficacy of Anti‐ PD ‐ L1 Immunotherapy in CRC Through the STAT1 / CXCL10 Signaling Axis

doi: 10.1111/cas.70530

Figure Lengend Snippet: SLAMF6 enhances anti‐PD‐L1 immunotherapy in CRC via the STAT1/CXCL10 axis. SLAMF6 activates STAT1 to upregulate CXCL10, promoting CD8 + T‐cell recruitment into CRC tumor microenvironment. Together with anti‐PD‐L1, this enhances ICI efficacy.

Article Snippet: The primary antibodies used in this study were as follows: anti‐SLAMF6 (1:100, Abcam, ab213690), anti‐CD3 (1:100, Abcam, ab16669), anti‐CD8 (1:500, Cell Signaling Technology, #98941, Danvers, MA, USA), anti‐Ki67 (1:200, Proteintech, 27309‐1‐AP), anti‐CXCL10 (1:100, absin, abs135937), anti‐IFN‐γ (1:300, Proteintech, 15365‐1‐AP), and anti‐PD‐L1 (1:1000, Proteintech, 28076‐1‐AP).

Techniques:

Journal: Cell metabolism

Article Title: Host Metadherin Coordinates Hepatic Lipid metabolism and CD8 + T-Cell Immunity to Promote Tumor Progression

doi: 10.1016/j.cmet.2026.08.003

Figure Lengend Snippet: ( A ) Schematic of the anti-PD-1 treatment experiments. ( B-C ) Primary growth of Py8119 tumors ( B ) and tumor-free survival from two independent experiments ( C ). n=6,5,5 and 6 mice in ( B ); n=12,12,10, and 12 mice in ( C ). ( D ) Survival in the Py8119 lung metastasis model. n=10. ( E-F ) Progression-free survival of MC38 tumors ( E ) and pie charts showing treatment responses in each group ( F ). n=10. ( G ) Schematic of ASO and T cell transfer treatment in the MC38-Ova model. ( H-J ) Individual tumor growth curves ( H ), final tumor volumes ( I ), and maximal tumor reduction ratio ( J ) after combined treatment. Numbers in ( H ) indicate the fraction of large and small tumors based on the cutoff line. In ( J ), the maximal tumor reduction ratio was calculated as the minimum tumor volume after combined treatment divided by the pretreatment tumor volume and is shown for individual tumors (left) and by group (right). Control mice received PBS. n=10, 22, and 22 tumors. Data are shown as mean ± SEM. Two-way ANOVA ( B ), log-rank (Mantel-Cox) test ( C, D, E ), and two-tailed unpaired Student’s t test ( I, J ).

Article Snippet: InVivoPlus anti-mouse PD-1 (CD279) (clone RMP1-14) , Bio X Cell , Cat#BE0146; RRID: AB_10949053.

Techniques: Control, Two Tailed Test