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p300  (Santa Cruz Biotechnology)
97
Santa Cruz Biotechnology p300
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
P300, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pcdna3 1 p300  (Addgene inc)
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Addgene inc pcdna3 1 p300
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
Pcdna3 1 P300, supplied by Addgene inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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6xhis p300 bd  (Addgene inc)
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Addgene inc 6xhis p300 bd
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
6xhis P300 Bd, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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primary antibodies against ep300  (Boster Bio)
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Boster Bio primary antibodies against ep300
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
Primary Antibodies Against Ep300, supplied by Boster Bio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p300/Anti-KAT3B%2Fp300%2FEP300+Antibody+Picoband/10__1007_slash_s10238___026___02270___9-96-0-4
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primary antibodies against ep300 - by Bioz Stars, 2026-10
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p300 150 inhibitor c646  (MedChemExpress)
97
MedChemExpress p300 150 inhibitor c646
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
P300 150 Inhibitor C646, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p300/C646/pm42575452-54-9-19
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p300 inhibitor a 485  (MedChemExpress)
97
MedChemExpress p300 inhibitor a 485
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
P300 Inhibitor A 485, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p300 cbp inhibitor  (MedChemExpress)
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MedChemExpress p300 cbp inhibitor
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
P300 Cbp Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p300/A-485/pm42447569-244-13-16
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p300  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc p300
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
P300, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p300/p300+Rabbit+mAb/pm41791566-70-13-14
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mouse anti p300 antibody  (Santa Cruz Biotechnology)
97
Santa Cruz Biotechnology mouse anti p300 antibody
<t>P300</t> interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.
Mouse Anti P300 Antibody, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p300/p300+Antibody/pm41703985-74-21-29
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P300 interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.

Journal: Advanced Science

Article Title: H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

doi: 10.1002/advs.78220

Figure Lengend Snippet: P300 interacts with and regulates H4K12la to modulate cellular energy metabolism in PD models. (A) RT‐qPCR analysis of P300, GCN5, HBO1, HDAC6, TIP60 mRNA expression in SN4741 cells treated with or without MPP + (N = 3). (B) Western blotting analysis and quantification of P300 protein levels in SN4741 cells treated with or without MPP + (N = 3). (C) Co‐IP assays showing reciprocal binding between P300 and H4K12la in MPP + ‐treated SN4741 cells (N = 3). (D) Representative immunofluorescence images showing the co‐localization of P300 (red) and H4K12la (green) in the nucleus of SN4741 cells, and (E) the quantitative analysis of co‐localization. DAPI (blue) stains nuclei (N = 3). Scale bar, 50 µm. (F) Predicted molecular docking model of the interaction between P300 and H4K12la, generated using the STRING database, indicating the presence of six hydrogen bonds. (G) Western blotting analysis of H4K12la and HIF‐1α protein levels in SN4741 cells treated with MPP + in the presence or absence of the indicated concentrations of A‐485 (N = 3). (H) Intracellular ATP levels in SN4741 cells treated with MPP + and/or A‐485 (N = 3). Data are presented as mean ± SEM. ns, not significant, * p < 0.05, ** p < 0.01, and *** p < 0.001. Statistical significance was determined by one‐way ANOVA or Student's t‐test as appropriate. “N” refers to the number of biologically independent experiments.

Article Snippet: The primary antibodies used in this study were as follows: GAPDH Monoclonal antibody (60004‐1‐Ig; ProteinTech, China), Pan‐Kla (PTM‐1401RM; PTM Biolabs, China), H4K12la (PTM‐1411RM; PTM Biolabs, China), H3K18la (PTM‐1406RM; PTM Biolabs, China), H3K23la (PTM‐1413RM; PTM Biolabs, China), H3K9la (PTM‐1419RM; PTM Biolabs, China), H3K14la (PTM‐1414RM; PTM Biolabs, China), H3 (PTM‐1001RM; PTM Biolabs, China), TH (MAB318; Sigma‐Aldrich, USA), HIF‐1α (PA1‐16601; Thermo Fisher Scientific, USA), NDUFS1 (PTM‐20288; PTM Biolabs, China), ATPB (A5769; ABclonal Biotechnology, China), P300 (sc‐48343; Santa Cruz Biotechnology, USA), β‐actin (4970; Cell Signaling Technology, USA), IBA1 (RT1316; BUABIO, China), HK2 (66974‐1‐Ig; ProteinTech, China), LDHA ( R24822 ; Zenbio, China).

Techniques: Quantitative RT-PCR, Analysis, Expressing, Western Blot, Co-Immunoprecipitation Assay, Binding Assay, Immunofluorescence, Docking Assay, Generated