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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
Vdac1 Oligomerization Inhibitor Vbit, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
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detergent soluble fractions  (Biosensis ltd)
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
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bek 2215 1p  (Biosensis ltd)
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
Aminoethylaminopropylisobutyl Polyhedral Oligomeric Silsesquioxane, supplied by Hybrid Plastics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
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homo oligomeric proteins  (Seca)
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Drp1-dependent <t>VDAC1</t> oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) <t>or</t> <t>VBIT-4</t> (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.
Homo Oligomeric Proteins, supplied by Seca, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Drp1-dependent VDAC1 oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) or VBIT-4 (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.

Journal: Journal of Oral Microbiology

Article Title: P. gingivalis induces endothelial dysfunction via mitochondrial fission dependent VDAC1-HK2 disassociation

doi: 10.1080/20002297.2026.2643035

Figure Lengend Snippet: Drp1-dependent VDAC1 oligomerization is required for P. gingivalis induced mitochondrial dysfunction. HAECs was pretreated with or without Mdivi-1 (50 μM) and then infected with P. gingivalis for 24 h (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and p -Drp1 (green) in HAECs. Scale bars: 20 μm (original) and 2 μm (Zoom). (C) The interaction of p -Drp1 and VDAC1 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Immunoblot of VDAC1 cross-linking in HAECs pretreated with Mdivi-1 (50 μM) or VBIT-4 (20 μM) and quantitative analysis of oligomers. ( n = 3). (F, G) Calcein, MitoSOX staining assay and quantitative bar chart. Scale bars = 20 μm. ( n = 3) (H, I) Tube formation assay and quantitative bar chart. Scale bars = 200 μm. ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. * P < 0.05. *** P < 0.001.

Article Snippet: Mdivi-1, the mPTP inhibitor cyclosporin A (CsA), and the VDAC1 oligomerization inhibitor VBIT-4 were purchased from TargetMol (USA).

Techniques: Infection, Immunofluorescence, Immunoprecipitation, Western Blot, Staining, Tube Formation Assay

P. gingivalis triggers HK2 dissociation from VDAC1. HAECs were pretreated with Mdivi-1 (50 μM) or VBIT-4 (20 μM), followed by infection with P. gingivalis for 24 h. (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and HK2 (green) in HAECs. Scale bars: 20 μm (original) and 5 μm (Zoom). (C) The interaction of VDAC1 and HK2 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Representative immunoblots and quantification of HK2 levels in cytosolic and mitochondrial fractions of HAECs ( n = 3). (F, G) Representative immunofluorescence images and statistics analysis showing the co-location of mitochondria (red) and HK2 (green) in HAECs. Scale bars: 20 μm (original) and 5 μm (Zoom). ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. ns = not significant. * P < 0.05. ** P < 0.01. *** P < 0.001.

Journal: Journal of Oral Microbiology

Article Title: P. gingivalis induces endothelial dysfunction via mitochondrial fission dependent VDAC1-HK2 disassociation

doi: 10.1080/20002297.2026.2643035

Figure Lengend Snippet: P. gingivalis triggers HK2 dissociation from VDAC1. HAECs were pretreated with Mdivi-1 (50 μM) or VBIT-4 (20 μM), followed by infection with P. gingivalis for 24 h. (MOI = 100). (A, B) Representative immunofluorescence images and statistics analysis showing the co-location of VDAC1 (red) and HK2 (green) in HAECs. Scale bars: 20 μm (original) and 5 μm (Zoom). (C) The interaction of VDAC1 and HK2 was validated using Co-immunoprecipitation assays. ( n = 3). (D, E) Representative immunoblots and quantification of HK2 levels in cytosolic and mitochondrial fractions of HAECs ( n = 3). (F, G) Representative immunofluorescence images and statistics analysis showing the co-location of mitochondria (red) and HK2 (green) in HAECs. Scale bars: 20 μm (original) and 5 μm (Zoom). ( n = 3). Pg, P. gingivalis . All numbers ( n ) are biologically independent experiments. ns = not significant. * P < 0.05. ** P < 0.01. *** P < 0.001.

Article Snippet: Mdivi-1, the mPTP inhibitor cyclosporin A (CsA), and the VDAC1 oligomerization inhibitor VBIT-4 were purchased from TargetMol (USA).

Techniques: Infection, Immunofluorescence, Immunoprecipitation, Western Blot