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Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
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Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
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Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
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Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
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Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
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Abolishing the RNase activity of <t>Trax</t> leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.
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Abolishing the RNase activity of Trax leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.

Journal: iScience

Article Title: Genetic inactivation of Translin/Trax RNase disrupts miRNAs, hippocampal synaptic plasticity, and memory

doi: 10.1016/j.isci.2026.116188

Figure Lengend Snippet: Abolishing the RNase activity of Trax leads to significant alterations in the expression of genes involved in immune function, extracellular matrix, and integrin-mediated cell signaling in the hippocampus (A) Volcano plot shows the differentially expressed mRNAs in the hippocampus of TraxE126A mutants ( n = 4) compared to wildtype littermates ( n = 5). The upregulated and downregulated mRNAs (FDR<0.050 and log 2 fold change ≥0.263) are highlighted in red and blue, respectively. A full list of mRNAs analyzed is provided in . (B) Top 15 KEGG pathways from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. (C) Top 15 Gene Ontology (GO) Biological Process and (D) Molecular Function terms from the functional enrichment analysis of the differentially expressed mRNAs performed using the DAVID database. Also see for details of the DAVID functional enrichment analysis.

Article Snippet: • The Trax point-mutant mouse line used in this study (TraxE126A) is cryopreserved at the Jackson Laboratory (C57BL/6-Tsnax em1Jbar /J; Strain #035903) and is available by cryorecovery.

Techniques: Activity Assay, Expressing, Functional Assay