Journal: Frontiers in Child and Adolescent Psychiatry

Article Title: Maternal adverse childhood experiences and epigenetic aging in pediatric populations: a scoping review

doi: 10.3389/frcha.2026.1913117

Figure Lengend Snippet: Characteristics of the included studies.

Article Snippet: McKenna et al. (2024) , USA , Prospective cohort: (Pregnancy Study; Maternal Stress and Infant Microbiome Study; Echo Study) , 80 dyads , Mean 24.5 (range: 18–39) , Mean 3.04 (range: 1.96–4) , Birth or at ∼41-weeks equivalent gestational age , 10 item ACEs questionnaire + Child Trauma Questionnaire (CTQ) - short form (emotional, physical, sexual abuse) ( , ) , Tissue: Peripheral blood (spots/clots) Array: Illumina Infinium Methylation EPIC BeadChip Clock: Knight , No significant association between maternal ACEs and neonatal GEAA Higher infant Knight GEAA buffered the effect of maternal sexual abuse on children's internalizing ( β = −0.31, P = .004) and externalizing ( β = −0.28, P = 0.01) behavioral symptoms.

Techniques: Tissue, Methylation, Microbiome