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Demonstration of the effect of aPRP or PRGF on TGF-β and PDGF-BB expression in HCs and OACs at 2 or 3 h by ELISA. (A–D) TGF-β and (E–H) PDGF-BB expressions of 2.7% aPRP, 1.8% PGRF, or 4.3% L-PRP-administered HCs and OACs are given as mean standard deviation graphs for each time point in comparison with the control groups. One-way analysis of variance (ANOVA), Tukey’s HSD post hoc test (*): p < 0.05.

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Activated platelet rich plasma modulates the proliferation, apoptosis and matrix synthesis driven by growth factors in osteoarthritic chondrocytes: an in vitro study

doi: 10.3389/fbioe.2026.1940844

Figure Lengend Snippet: Demonstration of the effect of aPRP or PRGF on TGF-β and PDGF-BB expression in HCs and OACs at 2 or 3 h by ELISA. (A–D) TGF-β and (E–H) PDGF-BB expressions of 2.7% aPRP, 1.8% PGRF, or 4.3% L-PRP-administered HCs and OACs are given as mean standard deviation graphs for each time point in comparison with the control groups. One-way analysis of variance (ANOVA), Tukey’s HSD post hoc test (*): p < 0.05.

Article Snippet: TGF-β1 (#E-EL-H1657, Elabscience, Wuhan, China) and PDGF-BB (#E-EL-H1577, Elabscience, Wuhan, China) levels in the cell supernatant of OACs and HCs were evaluated by ELISA.

Techniques: Expressing, Enzyme-linked Immunosorbent Assay, Standard Deviation, Comparison, Control, Analysis

Flow diagram illustrates the overall design and study outcomes. Activated PRP at lower EC50 promotes OAC proliferation and apoptosis and induces collagen type-II, aggrecan, TGF-β and PDGF-BB expressions in OACs. Activated PRP may improve osteoarthritic joint function. This figure was created with AI assistance under the authors’ supervision. All conceptual content and final approval were provided by the authors.

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Activated platelet rich plasma modulates the proliferation, apoptosis and matrix synthesis driven by growth factors in osteoarthritic chondrocytes: an in vitro study

doi: 10.3389/fbioe.2026.1940844

Figure Lengend Snippet: Flow diagram illustrates the overall design and study outcomes. Activated PRP at lower EC50 promotes OAC proliferation and apoptosis and induces collagen type-II, aggrecan, TGF-β and PDGF-BB expressions in OACs. Activated PRP may improve osteoarthritic joint function. This figure was created with AI assistance under the authors’ supervision. All conceptual content and final approval were provided by the authors.

Article Snippet: TGF-β1 (#E-EL-H1657, Elabscience, Wuhan, China) and PDGF-BB (#E-EL-H1577, Elabscience, Wuhan, China) levels in the cell supernatant of OACs and HCs were evaluated by ELISA.

Techniques: