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Siglec-5 induces through the <t>HSF1/SYK/ERK1/2/SIRPα</t> signaling pathway. ( A) Western blot for detecting Siglec5, HSF1, NLRP3, p-SYK, p-ERK, p-ELK1, SIRPα, p-SHP2, and NOX4 protein expression. (B) Data statistics. Relative protein expression was quantified by densitometry using ImageJ and normalized to corresponding internal reference proteins (e.g., GAPDH or total protein). Data represent mean ± SD from three independent experiments. (C) CO-IP experiments confirmed the interaction; (C) Co-IP assays verified the interactions between Siglec5/HSF1 and ELK1/SIRPa.
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Siglec-5 induces through the <t>HSF1/SYK/ERK1/2/SIRPα</t> signaling pathway. ( A) Western blot for detecting Siglec5, HSF1, NLRP3, p-SYK, p-ERK, p-ELK1, SIRPα, p-SHP2, and NOX4 protein expression. (B) Data statistics. Relative protein expression was quantified by densitometry using ImageJ and normalized to corresponding internal reference proteins (e.g., GAPDH or total protein). Data represent mean ± SD from three independent experiments. (C) CO-IP experiments confirmed the interaction; (C) Co-IP assays verified the interactions between Siglec5/HSF1 and ELK1/SIRPa.
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Siglec-5 induces through the <t>HSF1/SYK/ERK1/2/SIRPα</t> signaling pathway. ( A) Western blot for detecting Siglec5, HSF1, NLRP3, p-SYK, p-ERK, p-ELK1, SIRPα, p-SHP2, and NOX4 protein expression. (B) Data statistics. Relative protein expression was quantified by densitometry using ImageJ and normalized to corresponding internal reference proteins (e.g., GAPDH or total protein). Data represent mean ± SD from three independent experiments. (C) CO-IP experiments confirmed the interaction; (C) Co-IP assays verified the interactions between Siglec5/HSF1 and ELK1/SIRPa.
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erk inhibition  (MedChemExpress)
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Siglec-5 induces through the <t>HSF1/SYK/ERK1/2/SIRPα</t> signaling pathway. ( A) Western blot for detecting Siglec5, HSF1, NLRP3, p-SYK, p-ERK, p-ELK1, SIRPα, p-SHP2, and NOX4 protein expression. (B) Data statistics. Relative protein expression was quantified by densitometry using ImageJ and normalized to corresponding internal reference proteins (e.g., GAPDH or total protein). Data represent mean ± SD from three independent experiments. (C) CO-IP experiments confirmed the interaction; (C) Co-IP assays verified the interactions between Siglec5/HSF1 and ELK1/SIRPa.
Erk Inhibition, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Siglec-5 induces through the HSF1/SYK/ERK1/2/SIRPα signaling pathway. ( A) Western blot for detecting Siglec5, HSF1, NLRP3, p-SYK, p-ERK, p-ELK1, SIRPα, p-SHP2, and NOX4 protein expression. (B) Data statistics. Relative protein expression was quantified by densitometry using ImageJ and normalized to corresponding internal reference proteins (e.g., GAPDH or total protein). Data represent mean ± SD from three independent experiments. (C) CO-IP experiments confirmed the interaction; (C) Co-IP assays verified the interactions between Siglec5/HSF1 and ELK1/SIRPa.

Journal: Frontiers in Medicine

Article Title: Siglec-5 suppresses LPS-induced acute lung injury via negative regulation of HSF1/SYK-mediated ROS production and pyroptosis

doi: 10.3389/fmed.2026.1799874

Figure Lengend Snippet: Siglec-5 induces through the HSF1/SYK/ERK1/2/SIRPα signaling pathway. ( A) Western blot for detecting Siglec5, HSF1, NLRP3, p-SYK, p-ERK, p-ELK1, SIRPα, p-SHP2, and NOX4 protein expression. (B) Data statistics. Relative protein expression was quantified by densitometry using ImageJ and normalized to corresponding internal reference proteins (e.g., GAPDH or total protein). Data represent mean ± SD from three independent experiments. (C) CO-IP experiments confirmed the interaction; (C) Co-IP assays verified the interactions between Siglec5/HSF1 and ELK1/SIRPa.

Article Snippet: HSF1 inhibitor Rocaglamide, SYK inhibitor Piceatannol, ERK1/2 activator mSIRK, and ELK1 inhibitor TAT-DEF-Elk-1 (TDE) were purchased from MCE.

Techniques: Western Blot, Expressing, Co-Immunoprecipitation Assay

Siglec-5 inhibits LPS-induced lung injury by modulating the HSF1/SYK/ERK1/2/SIRPα signaling pathway to suppress ROS and pyroptosis responses.

Journal: Frontiers in Medicine

Article Title: Siglec-5 suppresses LPS-induced acute lung injury via negative regulation of HSF1/SYK-mediated ROS production and pyroptosis

doi: 10.3389/fmed.2026.1799874

Figure Lengend Snippet: Siglec-5 inhibits LPS-induced lung injury by modulating the HSF1/SYK/ERK1/2/SIRPα signaling pathway to suppress ROS and pyroptosis responses.

Article Snippet: HSF1 inhibitor Rocaglamide, SYK inhibitor Piceatannol, ERK1/2 activator mSIRK, and ELK1 inhibitor TAT-DEF-Elk-1 (TDE) were purchased from MCE.

Techniques: