Journal: Frontiers in Cardiovascular Medicine

Article Title: ZnO nanoparticles induce acute arrhythmia and heart failure in mice by disturbing cardiac ion channels

doi: 10.3389/fcvm.2025.1569265

Figure Lengend Snippet: Effects of ZnO NPs on mice ECG. (A) Representative images showed the effects of ZnO NPs-40 at different doses and exposure duration on ECG in mice. (B) Representative images showed the effects of ZnO NPs-100 at different doses and exposure duration on ECG in mice. (C) Changes of PR-interval after different doses of ZnO NPs-40 for 0-60 min. (D) Changes of PR-interval after different doses of ZnO NPs-100 for 0-60 min. P, P wave; R, R wave; QRS-T, QRS complex and T wave; PVC, premature ventricular contractions; AVB, atrioventricular conduction block. * P < 0.05, ** P < 0.01, *** P < 0.001. n = 6 for control group; n = 6 for ZnO NPs-40 at 5 mg/kg group and 8 mg/kg group; n = 11 for ZnO NPs-40 at 10 mg/kg group; n = 7 for ZnO NPs-40 at 20 mg/kg group; n = 6 for ZnO NPs-100 at 5 mg/kg group, 10 mg/kg group and 20 mg/kg group; n = 10 for ZnO NPs-100 at 30 mg/kg group.

Article Snippet: 8–10 weeks male C57BL/6J mice were anesthetized with isoflurane, and ECGs were collected using a BIOPAC MP150 ECG data acquisition module (BIOPAC Systems, Inc., Goleta, CA, USA) before and after exposure to ZnO NPs for up to 60 min. ZnO NPs-40 were intravenously injected at doses of 5, 8, 10, and 20 mg/kg, while ZnO NPs-100 were administered at doses of 5, 10, 20, and 30 mg/kg.

Techniques: Blocking Assay, Control

Journal: Npj Biological Timing and Sleep

Article Title: Chronic circadian disruption alters cardiac function and glucose regulation in mice

doi: 10.1038/s44323-025-00032-6

Figure Lengend Snippet: The schematics on the left ( C , F , I , L ) illustrate the interval or wave amplitude of the respective cardiac parameters being measured in B6 ( A , D , G , J , M ) and BTBR ( B , E , H , K , N ) mice on the right. Male (blue) and female (red/pink) B6 and BTBR mice were conceived and housed in a matched (light blue/pink) or a mismatched (dark blue/red) LD cycle until 6 months old. At one, two, and four months old each group received an ECG and their heart rates ( A , B ), RR ( C – E ), QTc ( F – H ), JT ( I – K ) intervals, and R amplitude ( L – N ), were compared between groups overtime. BTBR hearts rates significantly differed between one month old and two months old ( p < 0.001) and one month old and four months old ( B ; p < 0.01), while RR intervals significantly differed between one month and two months old ( p < 0.001), one month and four months old ( p < 0.05), and two months and four months old ( E ; p < 0.01). B6 mice had longer JT intervals ( J ; p < 0.01) and longer RR intervals overtime ( D ; p < 0.05) in the mismatched LD cycle. QTc intervals in BTBR mice were significantly longer between one month old and two months old ( p < 0.001) and two months old and four months old ( H ; p < 0.05). At one month old, BTBR mice in the 24-h LD cycle had significantly longer JT intervals ( K ; p < 0.001) and significantly longer R amplitudes in females ( N ; p < 0.001). Significant interactions with LD cycle are boxed out in green, main effects of LD cycle, sex, and time are highlighted in orange, yellow, and purple, respectively.

Article Snippet: Using the ECG module in LabChart7 (ADinstruments), correct identification of each R complex was manually verified .

Techniques: