Journal: Journal of Antimicrobial Chemotherapy

Article Title: Cefiderocol activity against multidrug-resistant isolates from the PERSEUS study: relationship between cefiderocol minimum inhibitory concentration and clinical outcomes

doi: 10.1093/jac/dkag164

Figure Lengend Snippet: Correlation between MICs of cefiderocol obtained using (a) UMIC-lyophilised (Bruker) (b) ComAsp (Liofilchem) compared with the standard BMD method according to International Standard ISO 20776-1 guidelines and following EUCAST recommendations ( n = 57). MICs corresponding to essential agreement are depicted in grey, major error (ME) in green, and very major error (VME) in orange.

Article Snippet: The isolates included in this study presented a high selection bias, since they were not consecutive isolates but originated from a Shionogi compassionate use programme and an EAP in Spain, where cefiderocol was requested only when no other therapeutic options were available due to resistance or potential adverse events for life-threatening infections caused by Gram-negative bacteria.

Techniques:

Journal: Journal of Antimicrobial Chemotherapy

Article Title: Cefiderocol activity against multidrug-resistant isolates from the PERSEUS study: relationship between cefiderocol minimum inhibitory concentration and clinical outcomes

doi: 10.1093/jac/dkag164

Figure Lengend Snippet: MIC distribution for cefiderocol for patients included in the primary analysis ( n = 51). MICs were obtained using the standard BMD method according to International Standard ISO 20776-1 guidelines and following EUCAST recommendations.

Article Snippet: The isolates included in this study presented a high selection bias, since they were not consecutive isolates but originated from a Shionogi compassionate use programme and an EAP in Spain, where cefiderocol was requested only when no other therapeutic options were available due to resistance or potential adverse events for life-threatening infections caused by Gram-negative bacteria.

Techniques:

Journal: mBio

Article Title: A Val292 substitution combined with an alanine duplication (ADUP) in the Ω loop of ADC β-lactamase confers reduced susceptibility to advanced β-lactam agents, including cefiderocol

doi: 10.1128/mbio.03518-25

Figure Lengend Snippet: MIC profiles of cefiderocol among ADC variants identified in CRAb clinical isolates. Scatter plot showing the distribution of cefiderocol MICs for each ADC variant. The x -axis represents individual ADC variants, and the y -axis represents the corresponding MIC values (µg/mL) plotted on a log 2 scale. Each dot corresponds to a single isolate. The horizontal line indicates the median MIC value.

Article Snippet: To examine the effects of the V292W substitution in ADC-30 or ADC-33 on cefiderocol resistance, tests were also performed using the Shionogi MIC Dry Plate Cefiderocol (Kyokuto Pharmaceutical Industrial Co., Ltd., Tokyo, Japan), which is commercially available in Japan and was used due to the limited availability of iron-depleted Mueller-Hinton broth.

Techniques: Variant Assay