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(A) A schematic of the analyses performed in this paper: non-pregnant versus pregnant women with or without COVID-19. (B) CD25 + FOXP3 + -expressing CD4 + T cell frequencies in PBMCs. (C and D) Left panels show CM (CD45RO + CCR7 + ) and right panels show EM (CD45RO + CCR7 − ) frequencies in CD4 + T cells (CD19 − <t>CD3</t> + CD4 + ) (C) and CD8 + (CD19 − CD3 + CD8 + ) T cells (D) in PBMCs. (E and F) Frequencies of CD8 + T cells expressing (E) PD-1 and Tim-3 and (F) IL-2 and TNF-α. Healthy (non-pregnant, n = 19; pregnant, n = 34), severe/critical COVID-19 (non-pregnant, n = 9; pregnant, n = 15), or convalescent COVID-19 (non-pregnant, n = 18; pregnant, n = 22). Data are shown as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.
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(A) A schematic of the analyses performed in this paper: non-pregnant versus pregnant women with or without COVID-19. (B) CD25 + FOXP3 + -expressing CD4 + T cell frequencies in PBMCs. (C and D) Left panels show CM (CD45RO + CCR7 + ) and right panels show EM (CD45RO + CCR7 − ) frequencies in CD4 + T cells (CD19 − <t>CD3</t> + CD4 + ) (C) and CD8 + (CD19 − CD3 + CD8 + ) T cells (D) in PBMCs. (E and F) Frequencies of CD8 + T cells expressing (E) PD-1 and Tim-3 and (F) IL-2 and TNF-α. Healthy (non-pregnant, n = 19; pregnant, n = 34), severe/critical COVID-19 (non-pregnant, n = 9; pregnant, n = 15), or convalescent COVID-19 (non-pregnant, n = 18; pregnant, n = 22). Data are shown as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.
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(A) A schematic of the analyses performed in this paper: non-pregnant versus pregnant women with or without COVID-19. (B) CD25 + FOXP3 + -expressing CD4 + T cell frequencies in PBMCs. (C and D) Left panels show CM (CD45RO + CCR7 + ) and right panels show EM (CD45RO + CCR7 − ) frequencies in CD4 + T cells (CD19 − CD3 + CD4 + ) (C) and CD8 + (CD19 − CD3 + CD8 + ) T cells (D) in PBMCs. (E and F) Frequencies of CD8 + T cells expressing (E) PD-1 and Tim-3 and (F) IL-2 and TNF-α. Healthy (non-pregnant, n = 19; pregnant, n = 34), severe/critical COVID-19 (non-pregnant, n = 9; pregnant, n = 15), or convalescent COVID-19 (non-pregnant, n = 18; pregnant, n = 22). Data are shown as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.

Journal: Cell reports

Article Title: SARS-CoV-2 infection elucidates features of pregnancy-specific immunity

doi: 10.1016/j.celrep.2024.114933

Figure Lengend Snippet: (A) A schematic of the analyses performed in this paper: non-pregnant versus pregnant women with or without COVID-19. (B) CD25 + FOXP3 + -expressing CD4 + T cell frequencies in PBMCs. (C and D) Left panels show CM (CD45RO + CCR7 + ) and right panels show EM (CD45RO + CCR7 − ) frequencies in CD4 + T cells (CD19 − CD3 + CD4 + ) (C) and CD8 + (CD19 − CD3 + CD8 + ) T cells (D) in PBMCs. (E and F) Frequencies of CD8 + T cells expressing (E) PD-1 and Tim-3 and (F) IL-2 and TNF-α. Healthy (non-pregnant, n = 19; pregnant, n = 34), severe/critical COVID-19 (non-pregnant, n = 9; pregnant, n = 15), or convalescent COVID-19 (non-pregnant, n = 18; pregnant, n = 22). Data are shown as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.

Article Snippet: Anti-Human CD3 AF700 , Thermo Fisher Scientific , Cat# 56-0038-82; RRID: AB_906220.

Techniques: Expressing

KEY RESOURCES TABLE

Journal: Cell reports

Article Title: SARS-CoV-2 infection elucidates features of pregnancy-specific immunity

doi: 10.1016/j.celrep.2024.114933

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: Anti-Human CD3 AF700 , Thermo Fisher Scientific , Cat# 56-0038-82; RRID: AB_906220.

Techniques: Blocking Assay, Clinical Proteomics, Recombinant, Cell Stimulation, DNA Library Preparation, Staining, Single-cell Analysis, Software