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Schematic representation of (a) SARS-Cov-2 virion and its structural protein (b) spike protein denoting S1 and S2 subunit and its binding with ACE2 receptor. [Created with BioRender.com .]

Journal: Analytical Chemistry

Article Title: Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease

doi: 10.1021/acs.analchem.3c05225

Figure Lengend Snippet: Schematic representation of (a) SARS-Cov-2 virion and its structural protein (b) spike protein denoting S1 and S2 subunit and its binding with ACE2 receptor. [Created with BioRender.com .]

Article Snippet: SARS-CoV-2 MassArray Test and Ethos Laboratories SARS-CoV-2 MALDI-TOF Assay , employed the Agena SARS-CoV-2 Panel test kit for the amplification and detection of SARS-CoV-2 RNA.

Techniques: Binding Assay

Schematic representation of the SARS-CoV-2 genome, which includes a single-stranded RNA having various Open Reading Frames (ORF1a, ORF1b, ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8a, ORF8b, ORF9b), leading to the formation of 16 nonstructural protein (nsps1–nsps16), structural proteins like S (spike protein) having the S1 subunit, which includes NTD, RBD, SD1, and SD2 and the S2 subunit, which contains FL, HR1, HR2, and TM. Other structural proteins are E (Envelop protein), M (Membrane protein), N (Nucleocapsid protein). PL-pro (papain-like protease), and 3CL-pro (cysteine proteases). [Created with BioRender.com .]

Journal: Analytical Chemistry

Article Title: Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease

doi: 10.1021/acs.analchem.3c05225

Figure Lengend Snippet: Schematic representation of the SARS-CoV-2 genome, which includes a single-stranded RNA having various Open Reading Frames (ORF1a, ORF1b, ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8a, ORF8b, ORF9b), leading to the formation of 16 nonstructural protein (nsps1–nsps16), structural proteins like S (spike protein) having the S1 subunit, which includes NTD, RBD, SD1, and SD2 and the S2 subunit, which contains FL, HR1, HR2, and TM. Other structural proteins are E (Envelop protein), M (Membrane protein), N (Nucleocapsid protein). PL-pro (papain-like protease), and 3CL-pro (cysteine proteases). [Created with BioRender.com .]

Article Snippet: SARS-CoV-2 MassArray Test and Ethos Laboratories SARS-CoV-2 MALDI-TOF Assay , employed the Agena SARS-CoV-2 Panel test kit for the amplification and detection of SARS-CoV-2 RNA.

Techniques: Membrane