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Input to Cheriff-CA1 neurons 3 days after optogenetic STDP. (A) Dodt-contrast image (40x objective) of the CA1 region with overlaid epifluorescence image. Black asterisks: CheRiff-eGFP expressing CA1 pyramidal neurons; white asterisks: NT CA1 pyramidal neurons suitable for recording. Scale bar 25 μm. (B) Yellow light (1 ms, 594 nm) on ChrimsonR-CA3 neurons EPSCs in CA1 neurons of a control (no oSTDP pairing) slice. EPSCs are recorded sequentially from CheRiff-CA1 pyramidal neurons (green, average of 10 gray individual EPSCs) and at least 3 NT CA1 neurons (black average of 10 gray individual EPSCs). (C) Automatically detected EPSC peak (red x) and slope (dashed red line, 20–60% peak) from individual CheRiff-CA1 neurons and the average of NT neurons. (D–F) Red and violet ticks indicate pre- (red) <t>and</t> <t>post-synaptic</t> (violet) light stimulation. (D) Normalized input strength of CheRiff-CA1 neurons recorded from nonpaired control (left: no light stimulation; right: postsynaptic stimulation only) slices and mKate2-CA1 neurons 3 days later. mean ± SEM. n = 12; 7; 10 (left to right). (E) Normalized input strength of CheRiff-CA1 neurons 3 days after 300 pairings of single presynaptic and 3 postsynaptic spikes at 5 Hz. During anticausal pairing the last postsynaptic spike occurred −50 or − 10 ms before the EPSP. During causal pairing the first postsynaptic spike occurred +10 or + 50 ms after the EPSP. n = 10; 24; 25; 10 (left to right). * P < 0.05, *** P < 0.001. (F) Same as (E), but the pairing frequency was reduced to 0.1 Hz (360 pairings in 1 h) or the NMDA receptor antagonist <t>CPPene</t> (1 μM) was in the culture medium (±10 ms pairing 300x at 5 Hz. n = 5; 14; 14; 13, left to right). (G) Mean input strength (data from E) as a function of timing between EPSPs (red) and postsynaptic spike bursts (violet, at mean) at 5 Hz repetition frequency. Two complete cycles are illustrated.
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Input to Cheriff-CA1 neurons 3 days after optogenetic STDP. (A) Dodt-contrast image (40x objective) of the CA1 region with overlaid epifluorescence image. Black asterisks: CheRiff-eGFP expressing CA1 pyramidal neurons; white asterisks: NT CA1 pyramidal neurons suitable for recording. Scale bar 25 μm. (B) Yellow light (1 ms, 594 nm) on ChrimsonR-CA3 neurons EPSCs in CA1 neurons of a control (no oSTDP pairing) slice. EPSCs are recorded sequentially from CheRiff-CA1 pyramidal neurons (green, average of 10 gray individual EPSCs) and at least 3 NT CA1 neurons (black average of 10 gray individual EPSCs). (C) Automatically detected EPSC peak (red x) and slope (dashed red line, 20–60% peak) from individual CheRiff-CA1 neurons and the average of NT neurons. (D–F) Red and violet ticks indicate pre- (red) <t>and</t> <t>post-synaptic</t> (violet) light stimulation. (D) Normalized input strength of CheRiff-CA1 neurons recorded from nonpaired control (left: no light stimulation; right: postsynaptic stimulation only) slices and mKate2-CA1 neurons 3 days later. mean ± SEM. n = 12; 7; 10 (left to right). (E) Normalized input strength of CheRiff-CA1 neurons 3 days after 300 pairings of single presynaptic and 3 postsynaptic spikes at 5 Hz. During anticausal pairing the last postsynaptic spike occurred −50 or − 10 ms before the EPSP. During causal pairing the first postsynaptic spike occurred +10 or + 50 ms after the EPSP. n = 10; 24; 25; 10 (left to right). * P < 0.05, *** P < 0.001. (F) Same as (E), but the pairing frequency was reduced to 0.1 Hz (360 pairings in 1 h) or the NMDA receptor antagonist <t>CPPene</t> (1 μM) was in the culture medium (±10 ms pairing 300x at 5 Hz. n = 5; 14; 14; 13, left to right). (G) Mean input strength (data from E) as a function of timing between EPSPs (red) and postsynaptic spike bursts (violet, at mean) at 5 Hz repetition frequency. Two complete cycles are illustrated.
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Input to Cheriff-CA1 neurons 3 days after optogenetic STDP. (A) Dodt-contrast image (40x objective) of the CA1 region with overlaid epifluorescence image. Black asterisks: CheRiff-eGFP expressing CA1 pyramidal neurons; white asterisks: NT CA1 pyramidal neurons suitable for recording. Scale bar 25 μm. (B) Yellow light (1 ms, 594 nm) on ChrimsonR-CA3 neurons EPSCs in CA1 neurons of a control (no oSTDP pairing) slice. EPSCs are recorded sequentially from CheRiff-CA1 pyramidal neurons (green, average of 10 gray individual EPSCs) and at least 3 NT CA1 neurons (black average of 10 gray individual EPSCs). (C) Automatically detected EPSC peak (red x) and slope (dashed red line, 20–60% peak) from individual CheRiff-CA1 neurons and the average of NT neurons. (D–F) Red and violet ticks indicate pre- (red) <t>and</t> <t>post-synaptic</t> (violet) light stimulation. (D) Normalized input strength of CheRiff-CA1 neurons recorded from nonpaired control (left: no light stimulation; right: postsynaptic stimulation only) slices and mKate2-CA1 neurons 3 days later. mean ± SEM. n = 12; 7; 10 (left to right). (E) Normalized input strength of CheRiff-CA1 neurons 3 days after 300 pairings of single presynaptic and 3 postsynaptic spikes at 5 Hz. During anticausal pairing the last postsynaptic spike occurred −50 or − 10 ms before the EPSP. During causal pairing the first postsynaptic spike occurred +10 or + 50 ms after the EPSP. n = 10; 24; 25; 10 (left to right). * P < 0.05, *** P < 0.001. (F) Same as (E), but the pairing frequency was reduced to 0.1 Hz (360 pairings in 1 h) or the NMDA receptor antagonist <t>CPPene</t> (1 μM) was in the culture medium (±10 ms pairing 300x at 5 Hz. n = 5; 14; 14; 13, left to right). (G) Mean input strength (data from E) as a function of timing between EPSPs (red) and postsynaptic spike bursts (violet, at mean) at 5 Hz repetition frequency. Two complete cycles are illustrated.
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Input to Cheriff-CA1 neurons 3 days after optogenetic STDP. (A) Dodt-contrast image (40x objective) of the CA1 region with overlaid epifluorescence image. Black asterisks: CheRiff-eGFP expressing CA1 pyramidal neurons; white asterisks: NT CA1 pyramidal neurons suitable for recording. Scale bar 25 μm. (B) Yellow light (1 ms, 594 nm) on ChrimsonR-CA3 neurons EPSCs in CA1 neurons of a control (no oSTDP pairing) slice. EPSCs are recorded sequentially from CheRiff-CA1 pyramidal neurons (green, average of 10 gray individual EPSCs) and at least 3 NT CA1 neurons (black average of 10 gray individual EPSCs). (C) Automatically detected EPSC peak (red x) and slope (dashed red line, 20–60% peak) from individual CheRiff-CA1 neurons and the average of NT neurons. (D–F) Red and violet ticks indicate pre- (red) <t>and</t> <t>post-synaptic</t> (violet) light stimulation. (D) Normalized input strength of CheRiff-CA1 neurons recorded from nonpaired control (left: no light stimulation; right: postsynaptic stimulation only) slices and mKate2-CA1 neurons 3 days later. mean ± SEM. n = 12; 7; 10 (left to right). (E) Normalized input strength of CheRiff-CA1 neurons 3 days after 300 pairings of single presynaptic and 3 postsynaptic spikes at 5 Hz. During anticausal pairing the last postsynaptic spike occurred −50 or − 10 ms before the EPSP. During causal pairing the first postsynaptic spike occurred +10 or + 50 ms after the EPSP. n = 10; 24; 25; 10 (left to right). * P < 0.05, *** P < 0.001. (F) Same as (E), but the pairing frequency was reduced to 0.1 Hz (360 pairings in 1 h) or the NMDA receptor antagonist <t>CPPene</t> (1 μM) was in the culture medium (±10 ms pairing 300x at 5 Hz. n = 5; 14; 14; 13, left to right). (G) Mean input strength (data from E) as a function of timing between EPSPs (red) and postsynaptic spike bursts (violet, at mean) at 5 Hz repetition frequency. Two complete cycles are illustrated.
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Input to Cheriff-CA1 neurons 3 days after optogenetic STDP. (A) Dodt-contrast image (40x objective) of the CA1 region with overlaid epifluorescence image. Black asterisks: CheRiff-eGFP expressing CA1 pyramidal neurons; white asterisks: NT CA1 pyramidal neurons suitable for recording. Scale bar 25 μm. (B) Yellow light (1 ms, 594 nm) on ChrimsonR-CA3 neurons EPSCs in CA1 neurons of a control (no oSTDP pairing) slice. EPSCs are recorded sequentially from CheRiff-CA1 pyramidal neurons (green, average of 10 gray individual EPSCs) and at least 3 NT CA1 neurons (black average of 10 gray individual EPSCs). (C) Automatically detected EPSC peak (red x) and slope (dashed red line, 20–60% peak) from individual CheRiff-CA1 neurons and the average of NT neurons. (D–F) Red and violet ticks indicate pre- (red) and post-synaptic (violet) light stimulation. (D) Normalized input strength of CheRiff-CA1 neurons recorded from nonpaired control (left: no light stimulation; right: postsynaptic stimulation only) slices and mKate2-CA1 neurons 3 days later. mean ± SEM. n = 12; 7; 10 (left to right). (E) Normalized input strength of CheRiff-CA1 neurons 3 days after 300 pairings of single presynaptic and 3 postsynaptic spikes at 5 Hz. During anticausal pairing the last postsynaptic spike occurred −50 or − 10 ms before the EPSP. During causal pairing the first postsynaptic spike occurred +10 or + 50 ms after the EPSP. n = 10; 24; 25; 10 (left to right). * P < 0.05, *** P < 0.001. (F) Same as (E), but the pairing frequency was reduced to 0.1 Hz (360 pairings in 1 h) or the NMDA receptor antagonist CPPene (1 μM) was in the culture medium (±10 ms pairing 300x at 5 Hz. n = 5; 14; 14; 13, left to right). (G) Mean input strength (data from E) as a function of timing between EPSPs (red) and postsynaptic spike bursts (violet, at mean) at 5 Hz repetition frequency. Two complete cycles are illustrated.

Journal: Cerebral Cortex (New York, NY)

Article Title: Spike-timing-dependent plasticity rewards synchrony rather than causality

doi: 10.1093/cercor/bhac050

Figure Lengend Snippet: Input to Cheriff-CA1 neurons 3 days after optogenetic STDP. (A) Dodt-contrast image (40x objective) of the CA1 region with overlaid epifluorescence image. Black asterisks: CheRiff-eGFP expressing CA1 pyramidal neurons; white asterisks: NT CA1 pyramidal neurons suitable for recording. Scale bar 25 μm. (B) Yellow light (1 ms, 594 nm) on ChrimsonR-CA3 neurons EPSCs in CA1 neurons of a control (no oSTDP pairing) slice. EPSCs are recorded sequentially from CheRiff-CA1 pyramidal neurons (green, average of 10 gray individual EPSCs) and at least 3 NT CA1 neurons (black average of 10 gray individual EPSCs). (C) Automatically detected EPSC peak (red x) and slope (dashed red line, 20–60% peak) from individual CheRiff-CA1 neurons and the average of NT neurons. (D–F) Red and violet ticks indicate pre- (red) and post-synaptic (violet) light stimulation. (D) Normalized input strength of CheRiff-CA1 neurons recorded from nonpaired control (left: no light stimulation; right: postsynaptic stimulation only) slices and mKate2-CA1 neurons 3 days later. mean ± SEM. n = 12; 7; 10 (left to right). (E) Normalized input strength of CheRiff-CA1 neurons 3 days after 300 pairings of single presynaptic and 3 postsynaptic spikes at 5 Hz. During anticausal pairing the last postsynaptic spike occurred −50 or − 10 ms before the EPSP. During causal pairing the first postsynaptic spike occurred +10 or + 50 ms after the EPSP. n = 10; 24; 25; 10 (left to right). * P < 0.05, *** P < 0.001. (F) Same as (E), but the pairing frequency was reduced to 0.1 Hz (360 pairings in 1 h) or the NMDA receptor antagonist CPPene (1 μM) was in the culture medium (±10 ms pairing 300x at 5 Hz. n = 5; 14; 14; 13, left to right). (G) Mean input strength (data from E) as a function of timing between EPSPs (red) and postsynaptic spike bursts (violet, at mean) at 5 Hz repetition frequency. Two complete cycles are illustrated.

Article Snippet: Whole cell currents were recorded (see electrophysiology below) with synaptic transmission and action potentials blocked by CPPene (10 μM, Tocris bioscience; 1265), NBQX (10 μM, Tocris bioscience; 1044), picrotoxin (100 μM, Sigma; P1675-1G), and tetrodotoxin (TTX, 1 μM, HelloBio; HB1035).

Techniques: Expressing, Control