Review





Similar Products

bioactive compounds  (TargetMol)
94
TargetMol bioactive compounds
Bioactive Compounds, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Bioactive+Compounds+Library+Max/pm42826556-88-4-6
Average 94 stars, based on 1 article reviews
bioactive compounds - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
fda approved compound library  (Tocris)
95
Tocris fda approved compound library
Fda Approved Compound Library, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Tocriscreen+FDA-Approved+Drugs+Library/pm42816495-490-21-24
Average 95 stars, based on 1 article reviews
fda approved compound library - by Bioz Stars, 2026-10
95/100 stars
  Buy from Supplier
alkaloid library  (Selleck Chemicals)
93
Selleck Chemicals alkaloid library
Alkaloid Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Alkaloid+Compound+Library/pmc13655731-39-1-16
Average 93 stars, based on 1 article reviews
alkaloid library - by Bioz Stars, 2026-10
93/100 stars
  Buy from Supplier
compound library  (TargetMol)
95
TargetMol compound library
Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/JAK-STAT+Compound+Library/pm42767537-81-1-11
Average 95 stars, based on 1 article reviews
compound library - by Bioz Stars, 2026-10
95/100 stars
  Buy from Supplier
ferroptosis  (TargetMol)
96
TargetMol ferroptosis
Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.
Ferroptosis, supplied by TargetMol, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Ferroptosis+Compound+Library/pmc13316578-231-3-10
Average 96 stars, based on 1 article reviews
ferroptosis - by Bioz Stars, 2026-10
96/100 stars
  Buy from Supplier
ampk inhibitor compound c  (TargetMol)
93
TargetMol ampk inhibitor compound c
Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.
Ampk Inhibitor Compound C, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/AMPK-Targeted+Compound+Library/pm42546516-72-10-14
Average 93 stars, based on 1 article reviews
ampk inhibitor compound c - by Bioz Stars, 2026-10
93/100 stars
  Buy from Supplier
endoplasmic reticulum er stress compound library  (TargetMol)
94
TargetMol endoplasmic reticulum er stress compound library
Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.
Endoplasmic Reticulum Er Stress Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Endoplasmic+Reticulum+Stress+Compound+Library/pm42695676-209-1-0
Average 94 stars, based on 1 article reviews
endoplasmic reticulum er stress compound library - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
endoplasmic retic ulum er stress compound library  (TargetMol)
94
TargetMol endoplasmic retic ulum er stress compound library
Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.
Endoplasmic Retic Ulum Er Stress Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Endoplasmic+Reticulum+Stress+Compound+Library/pm42695676-166-29-28
Average 94 stars, based on 1 article reviews
endoplasmic retic ulum er stress compound library - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier
targetmol natural compound library  (TargetMol)
95
TargetMol targetmol natural compound library
Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.
Targetmol Natural Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Natural+Product+Library/pm42686984-62-1-1
Average 95 stars, based on 1 article reviews
targetmol natural compound library - by Bioz Stars, 2026-10
95/100 stars
  Buy from Supplier
bioactive dvanced science  (TargetMol)
94
TargetMol bioactive dvanced science
Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.
Bioactive Dvanced Science, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compound+library/Bioactive+Compounds+Library+Max/pm42667153-468-29-37
Average 94 stars, based on 1 article reviews
bioactive dvanced science - by Bioz Stars, 2026-10
94/100 stars
  Buy from Supplier

Image Search Results


Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.

Journal: Molecular Therapy Oncology

Article Title: PARP7 inhibitors enhance the immunogenic effects of radiation in pancreatic cancer cells

doi: 10.1016/j.omton.2026.201258

Figure Lengend Snippet: Transcriptome-wide induction of inflammatory response after radiation and PARP7 inhibition in PDAC cells (A, B) Quantification of differentially expressed (A) genes or (B) repetitive elements (fold-change>2, p < 0.05) in BxPC-3 and PANC-1 cells treated with 3 × 8 Gy without or with the PARP7 inhibitors KMR-206 (300 nM) and RBN-2397 (1 μM). PARP7 inhibitors were added 24 h before irradiation and kept until harvesting 72 h after the last irradiation. (A) Upregulated genes are shown in red, downregulated genes in blue. (B) Different categories of repetitive elements are shown with different colors. (C) Log2 fold changes in gene expression between indicated treated and control samples of most strongly upregulated repetitive elements. (D) Normalized enrichment scores (NESs) from gene set enrichment analysis (GSEA) for Hallmark gene sets (MSigDB) between indicated treatments and controls in PDAC cells. Shown are pathways significant in at least 3 comparisons with significance level p < 0.05 adjusted for multiple testing. (E) Log2 fold changes in gene expression between indicated treated and control samples of chosen genes involved in immune signaling or cell death pathways. The experiments were performed in three biological replicates.

Article Snippet: Apoptosis, necroptosis, and ferroptosis were inhibited using Q-VD-Oph (10 μM; TargetMol Chemicals), necrostatin-1 (10 μM; TargetMol Chemicals) and liproxstatin-1 (5 μM; TargetMol Chemicals), respectively.

Techniques: Inhibition, Irradiation, Gene Expression, Control, Analysis, RNA Sequencing