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Comprehensive comparison of scRNA-seq and spatial omics technologies in oncology.

Journal: Frontiers in Immunology

Article Title: Decoding the spatial logic of immune evasion in hepatocellular carcinoma: from single-cell profiling to spatial omics

doi: 10.3389/fimmu.2026.1935648

Figure Lengend Snippet: Comprehensive comparison of scRNA-seq and spatial omics technologies in oncology.

Article Snippet: Sequencing-based spatial transcriptomics , Visium (10x Genomics); Stereo-seq (BGI); Slide-seq , Whole-transcriptome mapping across large tissue areas; resolution ranges from multi-cellular spots to subcellular/nanoscale platforms. , Maps tissue-scale architecture, spatial gene modules, subclonal competition zones and tumor-stroma boundaries. , Resolution-sensitivity trade-off; multi-cellular spots require deconvolution; high sequencing cost..

Techniques: Comparison, Single Cell, Profiling, Sample Throughput, Sequencing, Spatial Transcriptomics, Tissue, Imaging, Sampling, In Situ, Transcriptomics, Functional Assay, Multiplexing, Biomarker Discovery