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Journal: Frontiers in Molecular Biosciences
Article Title: Lipopolysaccharide Alters the m6A Epitranscriptomic Tagging of RNAs in Cardiac Tissue
doi: 10.3389/fmolb.2021.670160
Figure Lengend Snippet: M 6 A modification profiles of lncRNA& mRNA in LPS and control group. (A) Volcano plots showing the lncRNAs that were differentially methylated between LPS and control group with statistical significance. (B) Volcano plots showing the mRNAs that were differentially methylated between LPS and control group with statistical significance (fold changes ≥1.5 and p < 0.05). (C) Hierarchical clustering analysis the differentially methylated lncRNAs. (D) Hierarchical clustering analysis the differentially methylated mRNAs. Ctrl, control; LPS, lipopolysaccharide.
Article Snippet: Probes specific for 27,770 mRNAs and 10,582 lncRNAs were used to analyze the samples from the LPS and control groups using an m 6 A mRNA and
Techniques: Modification, Control, Methylation
Journal: Frontiers in Molecular Biosciences
Article Title: Lipopolysaccharide Alters the m6A Epitranscriptomic Tagging of RNAs in Cardiac Tissue
doi: 10.3389/fmolb.2021.670160
Figure Lengend Snippet: The detailed information of the hyper-methylated and hypo-methylated lncRNAs.
Article Snippet: Probes specific for 27,770 mRNAs and 10,582 lncRNAs were used to analyze the samples from the LPS and control groups using an m 6 A mRNA and
Techniques:
Journal: Frontiers in Molecular Biosciences
Article Title: Lipopolysaccharide Alters the m6A Epitranscriptomic Tagging of RNAs in Cardiac Tissue
doi: 10.3389/fmolb.2021.670160
Figure Lengend Snippet: M 6 A single-base site qPCR was used to confirm the microarray data for the top four methylated lncRNAs and top six methylated mRNAs in left ventricle tissue between the LPS and control groups. * p < 0.05 versus the Ctrl group. Ctrl, control; LPS, lipopolysaccharide.
Article Snippet: Probes specific for 27,770 mRNAs and 10,582 lncRNAs were used to analyze the samples from the LPS and control groups using an m 6 A mRNA and
Techniques: Microarray, Methylation, Control
Journal: Frontiers in Molecular Biosciences
Article Title: Lipopolysaccharide Alters the m6A Epitranscriptomic Tagging of RNAs in Cardiac Tissue
doi: 10.3389/fmolb.2021.670160
Figure Lengend Snippet: LncRNA XR_346,771-miRNA-mRNA ceRNA analysis. (A) The ceRNA network of XR_346,771–miRNA–mRNA. Red circles represent miRNAs, blue circles represent mRNAs, and green circles represent lncRNAs. (B) Ten most enriched GO terms involved in the ceRNA network. (C) KEGG pathways involved in the ceRNA network. ceRNA, competing endogenous RNA.
Article Snippet: Probes specific for 27,770 mRNAs and 10,582 lncRNAs were used to analyze the samples from the LPS and control groups using an m 6 A mRNA and
Techniques:
Journal: Frontiers in Molecular Biosciences
Article Title: Lipopolysaccharide Alters the m6A Epitranscriptomic Tagging of RNAs in Cardiac Tissue
doi: 10.3389/fmolb.2021.670160
Figure Lengend Snippet: LncRNA XR_346771targeted miRNAs and mRNAs.
Article Snippet: Probes specific for 27,770 mRNAs and 10,582 lncRNAs were used to analyze the samples from the LPS and control groups using an m 6 A mRNA and
Techniques: